Usefulness of Next-Generation Sequencing for precision medicine in cancers: Report of three familial cases

Abstract

High-throughput next-generation sequencing has revolutionized cancer molecular diagnosis and research. Indeed, molecular analysis revealed that the same type of tumor may exhibit diverse molecular subgroups. This technology enables the identification of novel specific genes implicated in tumor progression. Moreover, identification of specific mutations and active molecular pathways play a crucial role in identifying new drug targets. The present study highlights the clinical utility of next-generation sequencing in the management of cancer by reporting three patients with family cancer history (Li-Fraumeni syndrome, breast cancer, and colon cancer), observed in the Medical Genetics Department of Ibn Rochd University Hospital in Casablanca, Morocco.